癌症补硒剂量（癌症患者补硒剂量）

目的 对前瞻性队列研究进行系统回顾和荟萃分析，以调查蔬菜、水果、谷物、可溶性和不溶性纤维摄入总量与全因风险、心血管疾病 (CVD) 和癌症死亡率之间的关联，并定量评估方法通过在 2023 年 8 月之前搜索 PubMed、Embase 和 Web of science 来确定符合条件的研究。使用随机效应模型来计算汇总相对风险 (RR) 和 95% 置信区间 (CI)，并使用限制三次样条来对线性/非线性关联。结果膳食纤维的全因死亡率、CVD 死亡率和癌症死亡率的汇总 RR 分别为 0.90 (95% CI: 0.86,0.93)、0.87 (0.84,0.91)、0.91 (0.88,0.93)。观察到全因死亡率和心血管疾病死亡率与水果、蔬菜谷物和可溶性纤维的摄入量以及与谷物纤维摄入量相关的癌症死亡率。未发现不溶性纤维、蔬菜或水果纤维摄入量与癌症死亡率之间存在显着关联。剂量反应分析显示膳食纤维摄入量与全因死亡率存在显着的非线性关系，而其他因素则呈线性关系。结论较高的膳食纤维（包括不同类型和食物来源的纤维摄入量）与较低的死亡风险相关。我们的研究结果为膳食纤维摄入量与死亡率之间的关系提供了更全面的证据。系统评价注册 剂量反应分析显示膳食纤维摄入量与全因死亡率存在显着的非线性关系，而其他因素则呈线性关系。结论较高的膳食纤维（包括不同类型和食物来源的纤维摄入量）与较低的死亡风险相关。我们的研究结果为膳食纤维摄入量与死亡率之间的关系提供了更全面的证据。系统评价注册 剂量反应分析显示膳食纤维摄入量与全因死亡率存在显着的非线性关系，而其他因素则呈线性关系。结论较高的膳食纤维（包括不同类型和食物来源的纤维摄入量）与较低的死亡风险相关。我们的研究结果为膳食纤维摄入量与死亡率之间的关系提供了更全面的证据。系统评价注册，标识符：CRD42022338837。

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Dietary intake of total vegetable, fruit, cereal, soluble and insoluble fiber and risk of all-cause, cardiovascular, and cancer mortality: systematic review and dose–response meta-analysis of prospective cohort studies

ObjectivesTo conduct a systematic review and meta-analysis of prospective cohort studies to investigate the association between total, vegetable, fruit, cereal, soluble and insoluble fiber intake and risk of all causes, cardiovascular disease (CVD), and cancer mortality and quantitatively assess the dose–response relation。MethodsEligible studies were identified by searching PubMed, Embase and Web of science before August 2023。 Random effects models were used to calculate summary relative risk (RR) and 95% confidence intervals (CI) and restricted cubic splines to model the linear/non-linear association。

ResultsThe summary RR for all-cause, CVD and cancer mortality of dietary fiber was 0。90 (95% CI: 0。86,0。93), 0。87 (0。84,0。91), 0。91 (0。88,0。93), respectively。 Significant association was observed for all-cause and CVD mortality with fruit, vegetable cereal and soluble fiber intake and cancer mortality with cereal fiber intake。 No significant association was found for insoluble fiber, vegetable or fruit fiber intake and cancer mortality。 Dose-response analysis showed a significant non-linear relation of dietary fiber intake with all-cause mortality, and linear relation for others。

ConclusionsHigher dietary fiber including different type and food sources of fiber intake were associated with lower risk of mortality。 Our findings provide more comprehensive evidence on dietary fiber intake with mortality。Systematic review registration, identifier: CRD42022338837。